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Inhibition of cytochrome P450 3A by acetoxylated analogues of resveratrol in in vitro and in silico models
Many dietary compounds, including resveratrol, are potent inhibitors of CYP3A4. Here we examined the potential to predict inhibition capacity of dietary polyphenolics using an in silico and in vitro approaches and synthetic model compounds. Mono, di, and tri-acetoxy resveratrol were synthesized, a c...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4987671/ https://www.ncbi.nlm.nih.gov/pubmed/27530542 http://dx.doi.org/10.1038/srep31557 |