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Immunoproteasome dysfunction augments alternative polarization of alveolar macrophages

The proteasome is a central regulatory hub for intracellular signaling by degrading numerous signaling mediators. Immunoproteasomes are specialized types of proteasomes involved in shaping adaptive immune responses, but their role in innate immune signaling is still elusive. Here, we analyzed immuno...

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Detalles Bibliográficos
Autores principales: Chen, S, Kammerl, I E, Vosyka, O, Baumann, T, Yu, Y, Wu, Y, Irmler, M, Overkleeft, H S, Beckers, J, Eickelberg, O, Meiners, S, Stoeger, T
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4987736/
https://www.ncbi.nlm.nih.gov/pubmed/26990663
http://dx.doi.org/10.1038/cdd.2016.3