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Actionable pathways: interactive discovery of therapeutic targets using signaling pathway models

The discovery of actionable targets is crucial for targeted therapies and is also a constituent part of the drug discovery process. The success of an intervention over a target depends critically on its contribution, within the complex network of gene interactions, to the cellular processes responsi...

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Autores principales: Salavert, Francisco, Hidago, Marta R., Amadoz, Alicia, Çubuk, Cankut, Medina, Ignacio, Crespo, Daniel, Carbonell-Caballero, Jose, Dopazo, Joaquín
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4987920/
https://www.ncbi.nlm.nih.gov/pubmed/27137885
http://dx.doi.org/10.1093/nar/gkw369
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author Salavert, Francisco
Hidago, Marta R.
Amadoz, Alicia
Çubuk, Cankut
Medina, Ignacio
Crespo, Daniel
Carbonell-Caballero, Jose
Dopazo, Joaquín
author_facet Salavert, Francisco
Hidago, Marta R.
Amadoz, Alicia
Çubuk, Cankut
Medina, Ignacio
Crespo, Daniel
Carbonell-Caballero, Jose
Dopazo, Joaquín
author_sort Salavert, Francisco
collection PubMed
description The discovery of actionable targets is crucial for targeted therapies and is also a constituent part of the drug discovery process. The success of an intervention over a target depends critically on its contribution, within the complex network of gene interactions, to the cellular processes responsible for disease progression or therapeutic response. Here we present PathAct, a web server that predicts the effect that interventions over genes (inhibitions or activations that simulate knock-outs, drug treatments or over-expressions) can have over signal transmission within signaling pathways and, ultimately, over the cell functionalities triggered by them. PathAct implements an advanced graphical interface that provides a unique interactive working environment in which the suitability of potentially actionable genes, that could eventually become drug targets for personalized or individualized therapies, can be easily tested. The PathAct tool can be found at: http://pathact.babelomics.org.
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spelling pubmed-49879202016-08-22 Actionable pathways: interactive discovery of therapeutic targets using signaling pathway models Salavert, Francisco Hidago, Marta R. Amadoz, Alicia Çubuk, Cankut Medina, Ignacio Crespo, Daniel Carbonell-Caballero, Jose Dopazo, Joaquín Nucleic Acids Res Web Server issue The discovery of actionable targets is crucial for targeted therapies and is also a constituent part of the drug discovery process. The success of an intervention over a target depends critically on its contribution, within the complex network of gene interactions, to the cellular processes responsible for disease progression or therapeutic response. Here we present PathAct, a web server that predicts the effect that interventions over genes (inhibitions or activations that simulate knock-outs, drug treatments or over-expressions) can have over signal transmission within signaling pathways and, ultimately, over the cell functionalities triggered by them. PathAct implements an advanced graphical interface that provides a unique interactive working environment in which the suitability of potentially actionable genes, that could eventually become drug targets for personalized or individualized therapies, can be easily tested. The PathAct tool can be found at: http://pathact.babelomics.org. Oxford University Press 2016-07-08 2016-05-02 /pmc/articles/PMC4987920/ /pubmed/27137885 http://dx.doi.org/10.1093/nar/gkw369 Text en © The Author(s) 2016. Published by Oxford University Press on behalf of Nucleic Acids Research. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Web Server issue
Salavert, Francisco
Hidago, Marta R.
Amadoz, Alicia
Çubuk, Cankut
Medina, Ignacio
Crespo, Daniel
Carbonell-Caballero, Jose
Dopazo, Joaquín
Actionable pathways: interactive discovery of therapeutic targets using signaling pathway models
title Actionable pathways: interactive discovery of therapeutic targets using signaling pathway models
title_full Actionable pathways: interactive discovery of therapeutic targets using signaling pathway models
title_fullStr Actionable pathways: interactive discovery of therapeutic targets using signaling pathway models
title_full_unstemmed Actionable pathways: interactive discovery of therapeutic targets using signaling pathway models
title_short Actionable pathways: interactive discovery of therapeutic targets using signaling pathway models
title_sort actionable pathways: interactive discovery of therapeutic targets using signaling pathway models
topic Web Server issue
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4987920/
https://www.ncbi.nlm.nih.gov/pubmed/27137885
http://dx.doi.org/10.1093/nar/gkw369
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