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ConSurf 2016: an improved methodology to estimate and visualize evolutionary conservation in macromolecules

The degree of evolutionary conservation of an amino acid in a protein or a nucleic acid in DNA/RNA reflects a balance between its natural tendency to mutate and the overall need to retain the structural integrity and function of the macromolecule. The ConSurf web server (http://consurf.tau.ac.il), e...

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Detalles Bibliográficos
Autores principales: Ashkenazy, Haim, Abadi, Shiran, Martz, Eric, Chay, Ofer, Mayrose, Itay, Pupko, Tal, Ben-Tal, Nir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4987940/
https://www.ncbi.nlm.nih.gov/pubmed/27166375
http://dx.doi.org/10.1093/nar/gkw408