The insights of Let‐7 miRNAs in oncogenesis and stem cell potency

The ability of the classic tumour‐suppressive let‐7 family to inhibit carcinogenesis, tumour progression, recurrence and pluripotency of cancer stem cells has generated significant interest in the field of cancer research. Through suppressing and degrading downstream‐targeted mRNAs, let‐7 affected m...

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Detalles Bibliográficos
Autores principales: Sun, Xin, Liu, Jian, Xu, Chongwen, Tang, Shou‐Ching, Ren, Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Review Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4988292/
https://www.ncbi.nlm.nih.gov/pubmed/27097729
http://dx.doi.org/10.1111/jcmm.12861
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author Sun, Xin
Liu, Jian
Xu, Chongwen
Tang, Shou‐Ching
Ren, Hong
author_facet Sun, Xin
Liu, Jian
Xu, Chongwen
Tang, Shou‐Ching
Ren, Hong
author_sort Sun, Xin
collection PubMed
description The ability of the classic tumour‐suppressive let‐7 family to inhibit carcinogenesis, tumour progression, recurrence and pluripotency of cancer stem cells has generated significant interest in the field of cancer research. Through suppressing and degrading downstream‐targeted mRNAs, let‐7 affected most aspects of cell biology. It is perplexing how let‐7 affects oncogenesis, as the large influx of new miRNAs and other kinds of non‐coding RNAs are continuously defined. In this review, we delineate the complex functions of let‐7 and discuss the future direction of let‐7 research.
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spelling pubmed-49882922016-09-01 The insights of Let‐7 miRNAs in oncogenesis and stem cell potency Sun, Xin Liu, Jian Xu, Chongwen Tang, Shou‐Ching Ren, Hong J Cell Mol Med Review Articles The ability of the classic tumour‐suppressive let‐7 family to inhibit carcinogenesis, tumour progression, recurrence and pluripotency of cancer stem cells has generated significant interest in the field of cancer research. Through suppressing and degrading downstream‐targeted mRNAs, let‐7 affected most aspects of cell biology. It is perplexing how let‐7 affects oncogenesis, as the large influx of new miRNAs and other kinds of non‐coding RNAs are continuously defined. In this review, we delineate the complex functions of let‐7 and discuss the future direction of let‐7 research. John Wiley and Sons Inc. 2016-04-21 2016-09 /pmc/articles/PMC4988292/ /pubmed/27097729 http://dx.doi.org/10.1111/jcmm.12861 Text en © 2016 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine. This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Articles
Sun, Xin
Liu, Jian
Xu, Chongwen
Tang, Shou‐Ching
Ren, Hong
The insights of Let‐7 miRNAs in oncogenesis and stem cell potency
title The insights of Let‐7 miRNAs in oncogenesis and stem cell potency
title_full The insights of Let‐7 miRNAs in oncogenesis and stem cell potency
title_fullStr The insights of Let‐7 miRNAs in oncogenesis and stem cell potency
title_full_unstemmed The insights of Let‐7 miRNAs in oncogenesis and stem cell potency
title_short The insights of Let‐7 miRNAs in oncogenesis and stem cell potency
title_sort insights of let‐7 mirnas in oncogenesis and stem cell potency
topic Review Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4988292/
https://www.ncbi.nlm.nih.gov/pubmed/27097729
http://dx.doi.org/10.1111/jcmm.12861
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