Cargando…

In Silico Structure Prediction of Human Fatty Acid Synthase–Dehydratase: A Plausible Model for Understanding Active Site Interactions

Fatty acid synthase (FASN, UniProt ID: P49327) is a multienzyme dimer complex that plays a critical role in lipogenesis. Consequently, this lipogenic enzyme has gained tremendous biomedical importance. The role of FASN and its inhibition is being extensively researched in several clinical conditions...

Descripción completa

Detalles Bibliográficos
Autores principales:	John, Arun, Umashankar, Vetrivel, Samdani, A., Sangeetha, Manoharan, Krishnakumar, Subramanian, Deepa, Perinkulam Ravi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Libertas Academica 2016
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4988464/ https://www.ncbi.nlm.nih.gov/pubmed/27559295 http://dx.doi.org/10.4137/BBI.S38317

Ejemplares similares

Comparative Modeling and Molecular Dynamics Simulation of Substrate Binding in Human Fatty Acid Synthase: Enoyl Reductase and β-Ketoacyl Reductase Catalytic Domains
por: John, Arun, et al.
Publicado: (2015)

A molecular model of human Lysyl Oxidase (LOX) with optimal copper orientation in the catalytic cavity for induced fit docking studies with potential modulators
por: Bhuvanasundar, Renganathan, et al.
Publicado: (2014)

In vitro and In silico studies on inhibitory effects of curcumin on multi drug resistance associated protein (MRP1) in retinoblastoma cells
por: Sreenivasan, Seethalakshmi, et al.
Publicado: (2012)

Computational and in vitro Investigation of miRNA-Gene Regulations in Retinoblastoma Pathogenesis: miRNA Mimics Strategy
por: Venkatesan, Nalini, et al.
Publicado: (2015)

PocketPipe: A computational pipeline for integrated Pocketome prediction and comparison
por: Ansar, Samdani, et al.
Publicado: (2019)

Modulation of multidrug resistance 1 expression and function in retinoblastoma cells by curcumin
por: Sreenivasan, Seethalakshmi, et al.
Publicado: (2013)

Molecular deregulation induced by silencing of the high mobility group protein A2 gene in retinoblastoma cells
por: Venkatesan, Nalini, et al.
Publicado: (2012)

Molecular Insights on Post-chemotherapy Retinoblastoma by Microarray Gene Expression Analysis
por: Nalini, Venkatesan, et al.
Publicado: (2013)

Identification and Insilico Analysis of Retinoblastoma Serum microRNA Profile and Gene Targets Towards Prediction of Novel Serum Biomarkers
por: Beta, Madhu, et al.
Publicado: (2013)

Elucidating the Therapeutic Potential of Cell-Penetrating Peptides in Human Tenon Fibroblast Cells
por: Chatterjee, Amit, et al.
Publicado: (2022)

Structural insights into dehydratase substrate selection for the borrelidin and fluvirucin polyketide synthases
por: Barajas, Jesus F., et al.
Publicado: (2019)

Diene Incorporation by a Dehydratase Domain Variant in Modular Polyketide Synthases
por: Hobson, Christian, et al.
Publicado: (2022)

Fatty Acid Synthase Beta Dehydratase in the Lipid Biosynthesis Pathway Is Required for Conidiogenesis, Pigmentation and Appressorium Formation in Magnaporthe oryzae S6
por: Sangappillai, Vaanee, et al.
Publicado: (2020)

Discovery of a novel dehydratase of the fatty acid synthase type II critical for ketomycolic acid biosynthesis and virulence of Mycobacterium tuberculosis
por: Lefebvre, Cyril, et al.
Publicado: (2020)

Inhibition of IKKβ by celastrol and its analogues – an in silico and in vitro approach
por: Veerappan, Karpagam, et al.
Publicado: (2016)

Modeling of phosphomethyl pyrimidine kinase from Leptospira interrogans serovar lai strain 56601
por: Umashankar, Vetrivel, et al.
Publicado: (2006)

InPACdb Indian plant anticancer compounds database
por: Vetrivel, Umashankar, et al.
Publicado: (2009)

Design of human immunodeficiency virus-1 neutralizing peptides targeting CD4-binding site: An integrative computational biologics approach
por: Vivekanandan, Sandhya, et al.
Publicado: (2022)

Recent Progress in the Understanding and Engineering of Coenzyme B(12)-Dependent Glycerol Dehydratase
por: Nasir, Abdul, et al.
Publicado: (2020)

Functional analysis of the dehydratase domains of the PUFA synthase from Emiliania huxleyi in Escherichia coli and Arabidopsis thaliana
por: Chen, Bihan, et al.
Publicado: (2022)

Clinico-Pathological Association of Delineated miRNAs in Uveal Melanoma with Monosomy 3/Disomy 3 Chromosomal Aberrations
por: Venkatesan, Nalini, et al.
Publicado: (2016)

Probing the intermolecular interactions of PPARγ-LBD with polyunsaturated fatty acids and their anti-inflammatory metabolites to infer most potential binding moieties
por: Muralikumar, Shalini, et al.
Publicado: (2017)

Discovery of Function in the Enolase Superfamily: d-Mannonate and d-Gluconate Dehydratases in the d-Mannonate Dehydratase Subgroup
por: Wichelecki, Daniel J., et al.
Publicado: (2014)

Molecular Evolution of Threonine Dehydratase in Bacteria
por: Yu, Xuefei, et al.
Publicado: (2013)

The crystal structure of D-xylonate dehydratase reveals functional features of enzymes from the Ilv/ED dehydratase family
por: Rahman, Mohammad Mubinur, et al.
Publicado: (2018)

Microsecond Simulation of the Proteoglycan-like Region of Carbonic Anhydrase IX and Design of Chemical Inhibitors Targeting pH Homeostasis in Cancer Cells
por: John, Arun, et al.
Publicado: (2020)

Open discovery: An integrated live Linux platform of Bioinformatics tools
por: Vetrivel, Umashankar, et al.
Publicado: (2008)

The Streptomyces viridochromogenes product template domain represents an evolutionary intermediate between dehydratase and aldol cyclase of type I polyketide synthases
por: Feng, Yuanyuan, et al.
Publicado: (2022)

Understanding the Uptake Mechanism and Interaction Potential of the Designed Peptide and Preparation of Composite Fiber Matrix for Fungal Keratitis
por: Chatterjee, Amit, et al.
Publicado: (2020)

Bio-conjugation of antioxidant peptide on surface-modified gold nanoparticles: a novel approach to enhance the radical scavenging property in cancer cell
por: Kalmodia, Sushma, et al.
Publicado: (2016)

A Plausible Role for the Presence of Internal Shine-Dalgarno Sites
por: Ponnala, Lalit
Publicado: (2010)

Bio-physically plausible visualization of highly scattering fluorescent neocortical models for in silico experimentation
por: Abdellah, Marwan, et al.
Publicado: (2017)

Structural analysis and molecular dynamics simulation studies of HIV-1 antisense protein predict its potential role in HIV replication and pathogenesis
por: Sathiyamani, Balakumaran, et al.
Publicado: (2023)

Redefining non-alcoholic fatty liver disease to metabolic associated fatty liver disease: Is this plausible?
por: Devi, Jalpa, et al.
Publicado: (2022)

Plausible Role of Stem Cell Types for Treating and Understanding the Pathophysiology of Depression
por: Sachdeva, Punya, et al.
Publicado: (2023)

Discovery of Selective Inhibitors of the Clostridium difficile Dehydroquinate Dehydratase
por: Ratia, Kiira, et al.
Publicado: (2014)

The Role of ACT-Like Subdomain in Bacterial Threonine Dehydratases
por: Yu, Xuefei, et al.
Publicado: (2014)

Agonistic effect of polyunsaturated fatty acids (PUFAs) and its metabolites on brain-derived neurotrophic factor (BDNF) through molecular docking simulation
por: Vetrivel, Umashankar, et al.
Publicado: (2012)

Plausibility or Honesty?
Publicado: (1890)

Plausible Involvement of Ethylene in Plant Ferroptosis: Prospects and Leads
por: Riyazuddin, Riyazuddin, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_8k2opgab1lo929soibm790lk4k