Pinpointing a Mechanistic Switch Between Ketoreduction and “Ene” Reduction in Short‐Chain Dehydrogenases/Reductases

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Three enzymes of the Mentha essential oil biosynthetic pathway are highly homologous, namely the ketoreductases (−)‐menthone:(−)‐menthol reductase and (−)‐menthone:(+)‐neomenthol reductase, and the “ene” reductase isopiperitenone reductase. We identified a rare catalytic residue substitution in the...

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Detalles Bibliográficos
Autores principales: Lygidakis, Antonios, Karuppiah, Vijaykumar, Hoeven, Robin, Ní Cheallaigh, Aisling, Leys, David, Gardiner, John M., Toogood, Helen S., Scrutton, Nigel S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4988501/
https://www.ncbi.nlm.nih.gov/pubmed/27411040
http://dx.doi.org/10.1002/anie.201603785

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4988501/
https://www.ncbi.nlm.nih.gov/pubmed/27411040
http://dx.doi.org/10.1002/anie.201603785

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