EWS‐FLI1 impairs aryl hydrocarbon receptor activation by blocking tryptophan breakdown via the kynurenine pathway

Ewing sarcoma (ES) is an aggressive pediatric tumor driven by the fusion protein EWS‐FLI1. We report that EWS‐FLI1 suppresses TDO2‐mediated tryptophan (TRP) breakdown in ES cells. Gene expression and metabolite analyses reveal an EWS‐FLI1‐dependent regulation of TRP metabolism. TRP consumption incre...

Descripción completa

Detalles Bibliográficos
Autores principales: Mutz, Cornelia N., Schwentner, Raphaela, Kauer, Maximilian O., Katschnig, Anna M., Kromp, Florian, Aryee, Dave N. T., Erhardt, Sophie, Goiny, Michel, Alonso, Javier, Fuchs, Dietmar, Kovar, Heinrich
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Research Letters
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4988508/
https://www.ncbi.nlm.nih.gov/pubmed/27282934
http://dx.doi.org/10.1002/1873-3468.12243

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4988508/
https://www.ncbi.nlm.nih.gov/pubmed/27282934
http://dx.doi.org/10.1002/1873-3468.12243

Ejemplares similares