Using a Human Challenge Model of Infection to Measure Vaccine Efficacy: A Randomised, Controlled Trial Comparing the Typhoid Vaccines M01ZH09 with Placebo and Ty21a

BACKGROUND: Typhoid persists as a major cause of global morbidity. While several licensed vaccines to prevent typhoid are available, they are of only moderate efficacy and unsuitable for use in children less than two years of age. Development of new efficacious vaccines is complicated by the human h...

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Detalles Bibliográficos
Autores principales: Darton, Thomas C., Jones, Claire, Blohmke, Christoph J., Waddington, Claire S., Zhou, Liqing, Peters, Anna, Haworth, Kathryn, Sie, Rebecca, Green, Christopher A., Jeppesen, Catherine A., Moore, Maria, Thompson, Ben A. V., John, Tessa, Kingsley, Robert A., Yu, Ly-Mee, Voysey, Merryn, Hindle, Zoe, Lockhart, Stephen, Sztein, Marcelo B., Dougan, Gordon, Angus, Brian, Levine, Myron M., Pollard, Andrew J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4988630/
https://www.ncbi.nlm.nih.gov/pubmed/27533046
http://dx.doi.org/10.1371/journal.pntd.0004926

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4988630/
https://www.ncbi.nlm.nih.gov/pubmed/27533046
http://dx.doi.org/10.1371/journal.pntd.0004926

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