Cargando…

Using a Human Challenge Model of Infection to Measure Vaccine Efficacy: A Randomised, Controlled Trial Comparing the Typhoid Vaccines M01ZH09 with Placebo and Ty21a

BACKGROUND: Typhoid persists as a major cause of global morbidity. While several licensed vaccines to prevent typhoid are available, they are of only moderate efficacy and unsuitable for use in children less than two years of age. Development of new efficacious vaccines is complicated by the human h...

Descripción completa

Detalles Bibliográficos
Autores principales:	Darton, Thomas C., Jones, Claire, Blohmke, Christoph J., Waddington, Claire S., Zhou, Liqing, Peters, Anna, Haworth, Kathryn, Sie, Rebecca, Green, Christopher A., Jeppesen, Catherine A., Moore, Maria, Thompson, Ben A. V., John, Tessa, Kingsley, Robert A., Yu, Ly-Mee, Voysey, Merryn, Hindle, Zoe, Lockhart, Stephen, Sztein, Marcelo B., Dougan, Gordon, Angus, Brian, Levine, Myron M., Pollard, Andrew J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4988630/ https://www.ncbi.nlm.nih.gov/pubmed/27533046 http://dx.doi.org/10.1371/journal.pntd.0004926

Ejemplares similares

Activation of Salmonella Typhi-Specific Regulatory T Cells in Typhoid Disease in a Wild-Type S. Typhi Challenge Model
por: McArthur, Monica A., et al.
Publicado: (2015)

Oral Wild-Type Salmonella Typhi Challenge Induces Activation of Circulating Monocytes and Dendritic Cells in Individuals Who Develop Typhoid Disease
por: Toapanta, Franklin R., et al.
Publicado: (2015)

An Outpatient, Ambulant-Design, Controlled Human Infection Model Using Escalating Doses of Salmonella Typhi Challenge Delivered in Sodium Bicarbonate Solution
por: Waddington, Claire S., et al.
Publicado: (2014)

Salmonella Typhi-specific multifunctional CD8+ T cells play a dominant role in protection from typhoid fever in humans
por: Fresnay, Stephanie, et al.
Publicado: (2016)

Importance of Salmonella Typhi-Responsive CD8+ T Cell Immunity in a Human Typhoid Fever Challenge Model
por: Fresnay, Stephanie, et al.
Publicado: (2017)

Blood culture-PCR to optimise typhoid fever diagnosis after controlled human infection identifies frequent asymptomatic cases and evidence of primary bacteraemia
por: Darton, Thomas C., et al.
Publicado: (2017)

Mucosal-Associated Invariant T cells exhibit distinct functional signatures associated with protection against typhoid fever
por: Salerno-Gonçalves, Rosângela, et al.
Publicado: (2022)

Systemic and Terminal Ileum Mucosal Immunity Elicited by Oral Immunization With the Ty21a Typhoid Vaccine in Humans
por: Booth, Jayaum S., et al.
Publicado: (2017)

Challenge of Humans with Wild-type Salmonella enterica Serovar Typhi Elicits Changes in the Activation and Homing Characteristics of Mucosal-Associated Invariant T Cells
por: Salerno-Goncalves, Rosângela, et al.
Publicado: (2017)

Oral Challenge with Wild-Type Salmonella Typhi Induces Distinct Changes in B Cell Subsets in Individuals Who Develop Typhoid Disease
por: Toapanta, Franklin R., et al.
Publicado: (2016)

Assessment and Translation of the Antibody-in-Lymphocyte Supernatant (ALS) Assay to Improve the Diagnosis of Enteric Fever in Two Controlled Human Infection Models and an Endemic Area of Nepal
por: Darton, Thomas C., et al.
Publicado: (2017)

Interferon-driven alterations of the host’s amino acid metabolism in the pathogenesis of typhoid fever
por: Blohmke, Christoph J., et al.
Publicado: (2016)

A Randomised Trial Evaluating the Safety and Immunogenicity of the Novel Single Oral Dose Typhoid Vaccine M01ZH09 in Healthy Vietnamese Children
por: Hien, Tran Tinh, et al.
Publicado: (2010)

Immunization with Ty21a live oral typhoid vaccine elicits cross-reactive multifunctional CD8+ T cell responses against Salmonella enterica serovar Typhi, S. Paratyphi A and S. Paratyphi B in humans
por: Wahid, Rezwanul, et al.
Publicado: (2015)

An Appraisal of the Clinical Features of Pediatric Enteric Fever: Systematic Review and Meta-analysis of the Age-Stratified Disease Occurrence
por: Britto, Carl, et al.
Publicado: (2017)

The Impact of Vaccination and Prior Exposure on Stool Shedding of Salmonella Typhi and Salmonella Paratyphi in 6 Controlled Human Infection Studies
por: Gibani, Malick M, et al.
Publicado: (2019)

Effect of the live oral attenuated typhoid vaccine, Ty21a, on systemic and terminal ileum mucosal CD4(+) T memory responses in humans
por: Booth, Jayaum S, et al.
Publicado: (2018)

Induction of Cell Cycle and NK Cell Responses by Live-Attenuated Oral Vaccines against Typhoid Fever
por: Blohmke, Christoph J., et al.
Publicado: (2017)

Human Salmonella Typhi exposure generates differential multifunctional cross‐reactive T‐cell memory responses against Salmonella Paratyphi and invasive nontyphoidal Salmonella
por: Rapaka, Rekha R, et al.
Publicado: (2020)

Evaluation of the Clinical and Microbiological Response to Salmonella Paratyphi A Infection in the First Paratyphoid Human Challenge Model
por: Dobinson, Hazel C., et al.
Publicado: (2017)

Radiative corrections to e+e- --> ZH
por: Denner, A, et al.
Publicado: (1992)

ChAdOx1 nCoV-19 vaccine for SARS-CoV-2 – Authors' reply
por: Voysey, Merryn, et al.
Publicado: (2020)

Association between S. Typhi-specific memory CD4+ and CD8+ T responses in the terminal ileum mucosa and in peripheral blood elicited by the live oral typhoid vaccine Ty21a in humans
por: Booth, Jayaum S., et al.
Publicado: (2019)

The Design and Analysis of Seroefficacy Studies for Typhoid Conjugate Vaccines
por: Liu, Xinxue, et al.
Publicado: (2019)

Attenuated Oral Typhoid Vaccine Ty21a Elicits Lamina Propria and Intra-Epithelial Lymphocyte Tissue-Resident Effector Memory CD8 T Responses in the Human Terminal Ileum
por: Booth, Jayaum S., et al.
Publicado: (2019)

Oral typhoid vaccine Ty21a elicits antigen-specific resident memory CD4(+) T cells in the human terminal ileum lamina propria and epithelial compartments
por: Booth, Jayaum S., et al.
Publicado: (2020)

A->Zh->lltautau in ATLAS
por: Sales De Bruin, Pedro Henrique
Publicado: (2015)

Assessing sex-differences and the effect of timing of vaccination on immunogenicity, reactogenicity and efficacy of vaccines in young children: study protocol for an individual participant data meta-analysis of randomised controlled trials
por: Voysey, Merryn, et al.
Publicado: (2016)

Heterogeneity of Multifunctional IL-17A Producing S. Typhi-Specific CD8+ T Cells in Volunteers following Ty21a Typhoid Immunization
por: McArthur, Monica A., et al.
Publicado: (2012)

Rapidly Escalating Hepcidin and Associated Serum Iron Starvation Are Features of the Acute Response to Typhoid Infection in Humans
por: Darton, Thomas C., et al.
Publicado: (2015)

Computing threshold antibody levels of protection in vaccine clinical trials: An assessment of methodological bias
por: Voysey, Merryn, et al.
Publicado: (2018)

Compositional and Functional Differences in the Human Gut Microbiome Correlate with Clinical Outcome following Infection with Wild-Type Salmonella enterica Serovar Typhi
por: Zhang, Yan, et al.
Publicado: (2018)

Exploiting the WH/ZH symmetry in the search for New Physics
por: Harlander, R.V., et al.
Publicado: (2018)

Exploiting the WH/ZH symmetry in the search for new physics
por: Harlander, R. V., et al.
Publicado: (2018)

Nonspecific effects of oral vaccination with live-attenuated Salmonella Typhi strain Ty21a
por: Pennington, S. H., et al.
Publicado: (2019)

Modelling of loop-induced $ZH$-production in ATLAS
por: Windischhofer, Philipp
Publicado: (2022)

ZH Dark Photon Analysis with the ATLAS Experiment
por: Mohamed, Sondos
Publicado: (2021)

Development and Evaluation of a Blood Culture PCR Assay for Rapid Detection of Salmonella Paratyphi A in Clinical Samples
por: Zhou, Liqing, et al.
Publicado: (2016)

Age-Associated Heterogeneity of Ty21a-Induced T Cell Responses to HLA-E Restricted Salmonella Typhi Antigen Presentation
por: Rudolph, Mark E., et al.
Publicado: (2019)

Use of weighted multivariate estimates in trials of multi-serotype vaccines to simplify interpretation of treatment differences
por: Voysey, Merryn, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_irp5ma1fisitf222723hkim38l