GSK621 Targets Glioma Cells via Activating AMP-Activated Protein Kinase Signalings

Here, we studied the anti-glioma cell activity by a novel AMP-activated protein kinase (AMPK) activator GSK621. We showed that GSK621 was cytotoxic to human glioma cells (U87MG and U251MG lines), possibly via provoking caspase-dependent apoptotic cell death. Its cytotoxicity was alleviated by caspas...

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Detalles Bibliográficos
Autores principales: Jiang, Hong, Liu, Wei, Zhan, Shi-Kun, Pan, Yi-Xin, Bian, Liu-Guan, Sun, Bomin, Sun, Qing-Fang, Pan, Si-Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4988667/
https://www.ncbi.nlm.nih.gov/pubmed/27532105
http://dx.doi.org/10.1371/journal.pone.0161017

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4988667/
https://www.ncbi.nlm.nih.gov/pubmed/27532105
http://dx.doi.org/10.1371/journal.pone.0161017

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