Cargando…

GSK621 Targets Glioma Cells via Activating AMP-Activated Protein Kinase Signalings

Here, we studied the anti-glioma cell activity by a novel AMP-activated protein kinase (AMPK) activator GSK621. We showed that GSK621 was cytotoxic to human glioma cells (U87MG and U251MG lines), possibly via provoking caspase-dependent apoptotic cell death. Its cytotoxicity was alleviated by caspas...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jiang, Hong, Liu, Wei, Zhan, Shi-Kun, Pan, Yi-Xin, Bian, Liu-Guan, Sun, Bomin, Sun, Qing-Fang, Pan, Si-Jian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4988667/ https://www.ncbi.nlm.nih.gov/pubmed/27532105 http://dx.doi.org/10.1371/journal.pone.0161017

Ejemplares similares

Tetraspanin 8-Rictor-Integrin α3 Complex Is Required for Glioma Cell Migration
por: Pan, Si-Jian, et al.
Publicado: (2015)

Targeted activation of AMPK by GSK621 ameliorates H(2)O(2)-induced damages in osteoblasts
por: Liu, Weidong, et al.
Publicado: (2017)

The therapeutic value of XL388 in human glioma cells
por: Zhong, Shan, et al.
Publicado: (2020)

Ubiquitin-protein ligase E3C promotes glioma progression by mediating the ubiquitination and degrading of Annexin A7
por: Pan, Si-Jian, et al.
Publicado: (2015)

Regulation of cAMP and GSK3 signaling pathways contributes to the neuronal conversion of glioma
por: Oh, Jinsoo, et al.
Publicado: (2017)

ATP-Induced Inflammasome Activation and Pyroptosis Is Regulated by AMP-Activated Protein Kinase in Macrophages
por: Zha, Qing-Bing, et al.
Publicado: (2016)

Lip leishmaniasis: Clinical characteristics of 621 patients
por: Yeşilova, Yavuz, et al.
Publicado: (2015)

SUN-621 Lessons from beyond the Graves'
por: Chai, Thora, et al.
Publicado: (2019)

THU621 Mifepristone In Exogenous Cushing's Syndrome
por: Priyadarshan, Swetha, et al.
Publicado: (2023)

Lnc-THOR silencing inhibits human glioma cell survival by activating MAGEA6-AMPK signaling
por: Xue, Jun, et al.
Publicado: (2019)

AMPKα Subunit Ssp2 and Glycogen Synthase Kinases Gsk3/Gsk31 are involved in regulation of sterol regulatory element-binding protein (SREBP) activity in fission yeast
por: Miao, Hao, et al.
Publicado: (2020)

Protective effects of AMP-activated protein kinase in the cardiovascular system
por: Xu, Qiang, et al.
Publicado: (2010)

AMP-Activated Protein Kinase Signalling
por: Neumann, Dietbert, et al.
Publicado: (2019)

Berberine Promotes Glucose Consumption Independently of AMP-Activated Protein Kinase Activation
por: Xu, Miao, et al.
Publicado: (2014)

The role of AMP-activated protein kinase in GVHD-causing T cells
por: Ramgopal, Archana, et al.
Publicado: (2022)

Discovery of a natural small-molecule AMP-activated kinase activator that alleviates nonalcoholic steatohepatitis
por: Chen, Jin, et al.
Publicado: (2023)

Dual Roles of the AMP-Activated Protein Kinase Pathway in Angiogenesis
por: Li, Yuanjun, et al.
Publicado: (2019)

Participation of Hindbrain AMP-Activated Protein Kinase in Glucoprivic Feeding
por: Li, Ai-Jun, et al.
Publicado: (2011)

AMP-activated protein kinase: a therapeutic target in intestinal diseases
por: Sun, Xiaofei, et al.
Publicado: (2017)

Opposing Activity Changes in AMP Deaminase and AMP-Activated Protein Kinase in the Hibernating Ground Squirrel
por: Lanaspa, Miguel A., et al.
Publicado: (2015)

Hypothalamic AMP-Activated Protein Kinase Regulates Glucose Production
por: Yang, Clair S., et al.
Publicado: (2010)

Redox Regulation of the AMP-Activated Protein Kinase
por: Han, Yingying, et al.
Publicado: (2010)

Activation of AMP-activated protein kinase signaling pathway ameliorates steatosis in laying hen hepatocytes
por: Zhang, Kun, et al.
Publicado: (2020)

RNAseq analysis of α-proteobacterium Gluconobacter oxydans 621H
por: Kranz, Angela, et al.
Publicado: (2018)

Systematic exploration of the mechanical properties of 13 621 inorganic compounds
por: Chibani, Siwar, et al.
Publicado: (2019)

ODP621 Hypertension with Hypokalemia in Pregnancy? Think "Cushing's Syndrome"
por: Al Tameemi, Mohammed, et al.
Publicado: (2022)

Acetic Acid Activates the AMP-Activated Protein Kinase Signaling Pathway to Regulate Lipid Metabolism in Bovine Hepatocytes
por: Li, Xinwei, et al.
Publicado: (2013)

Regulation of AMP-activated protein kinase by natural and synthetic activators
por: Grahame Hardie, David
Publicado: (2016)

Hypoxia promotes drug resistance in osteosarcoma cells via activating AMP-activated protein kinase (AMPK) signaling
por: Zhao, Changfu, et al.
Publicado: (2016)

β‐Guanidinopropionic acid extends the lifespan of Drosophila melanogaster via an AMP‐activated protein kinase‐dependent increase in autophagy
por: Yang, Si, et al.
Publicado: (2015)

Non-cytotoxic doses of shikonin inhibit lipopolysaccharide-induced TNF-α expression via activation of the AMP-activated protein kinase signaling pathway
por: Zhang, Fang, et al.
Publicado: (2020)

Casein kinase II phosphorylation of cyclin F at serine 621 regulates the Lys48-ubiquitylation E3 ligase activity of the SCF((cyclin F)) complex
por: Lee, Albert, et al.
Publicado: (2017)

Cordycepin activates AMP-activated protein kinase (AMPK) via interaction with the γ1 subunit
por: Wu, Chongming, et al.
Publicado: (2014)

Melatonin alleviates lipopolysaccharide‐compromised integrity of blood–brain barrier through activating AMP‐activated protein kinase in old mice
por: Wang, Xiaona, et al.
Publicado: (2017)

Cross-talk between AMP-activated protein kinase and renin–angiotensin system in uninephrectomised rats
por: Yang, Ke-Ke, et al.
Publicado: (2016)

The exceptionally high reactivity of Cys 621 is critical for electrophilic activation of the sensory nerve ion channel TRPA1
por: Bahia, Parmvir K., et al.
Publicado: (2016)

MiRNA-621 sensitizes breast cancer to chemotherapy by suppressing FBXO11 and enhancing p53 activity
por: Xue, J, et al.
Publicado: (2016)

An environmental pollutant, 9,10‐phenanthrenequinone, activates human TRPA1 via critical cysteines 621 and 665
por: Muraki, Katsuhiko, et al.
Publicado: (2017)

Role of AMP-Activated Protein Kinase in the Control of Appetite
por: Kola, B
Publicado: (2008)

AMP-activated protein kinase: An emerging target for ginseng
por: Jeong, Kyong Ju, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_srdcomihmbe4lslekoa4npi360