Cystatin C Shifts APP Processing from Amyloid-β Production towards Non-Amyloidgenic Pathway in Brain Endothelial Cells

Amyloid-β (Aβ), the major component of neuritic plaques in Alzheimer’s disease (AD), is derived from sequential proteolytic cleavage of amyloid protein precursor (APP) by secretases. In this study, we found that cystatin C (CysC), a natural cysteine protease inhibitor, is able to reduce Aβ40 secreti...

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Detalles Bibliográficos
Autores principales: Wang, Xia-Fei, Liu, Dong-Xin, Liang, Yue, Xing, Li-Li, Zhao, Wen-Hui, Qin, Xiao-Xue, Shang, De-Shu, Li, Bo, Fang, Wen-Gang, Cao, Liu, Zhao, Wei-Dong, Chen, Yu-Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4988779/
https://www.ncbi.nlm.nih.gov/pubmed/27532339
http://dx.doi.org/10.1371/journal.pone.0161093

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4988779/
https://www.ncbi.nlm.nih.gov/pubmed/27532339
http://dx.doi.org/10.1371/journal.pone.0161093

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