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IGF1R Derived PI3K/AKT Signaling Maintains Growth in a Subset of Human T-Cell Acute Lymphoblastic Leukemias

Insulin-like growth factor 1 receptor (IGF1R) is a prevalent signaling pathway in human cancer that supports cell growth/survival and thus contributes to aggressive biological behavior. Much work has gone into development of IGF1R inhibitors; however, candidate agents including small molecule tyrosi...

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Detalles Bibliográficos
Autores principales:	Gusscott, Samuel, Jenkins, Catherine E., Lam, Sonya H., Giambra, Vincenzo, Pollak, Michael, Weng, Andrew P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4988785/ https://www.ncbi.nlm.nih.gov/pubmed/27532210 http://dx.doi.org/10.1371/journal.pone.0161158

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