IGF1R Derived PI3K/AKT Signaling Maintains Growth in a Subset of Human T-Cell Acute Lymphoblastic Leukemias

Insulin-like growth factor 1 receptor (IGF1R) is a prevalent signaling pathway in human cancer that supports cell growth/survival and thus contributes to aggressive biological behavior. Much work has gone into development of IGF1R inhibitors; however, candidate agents including small molecule tyrosi...

Descripción completa

Detalles Bibliográficos
Autores principales: Gusscott, Samuel, Jenkins, Catherine E., Lam, Sonya H., Giambra, Vincenzo, Pollak, Michael, Weng, Andrew P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4988785/
https://www.ncbi.nlm.nih.gov/pubmed/27532210
http://dx.doi.org/10.1371/journal.pone.0161158

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4988785/
https://www.ncbi.nlm.nih.gov/pubmed/27532210
http://dx.doi.org/10.1371/journal.pone.0161158

Ejemplares similares