TAL1 cooperates with PI3K/AKT pathway activation in T-cell acute lymphoblastic leukemia

TAL1 is ectopically expressed in about 30% of T-cell acute lymphoblastic leukemia (T-ALL) due to chromosomal rearrangements leading to the STIL-TAL1 fusion genes or due to non-coding mutations leading to a de novo enhancer driving TAL1 expression. Analysis of sequence data from T-ALL cases demonstra...

Descripción completa

Detalles Bibliográficos
Autores principales: Thielemans, Naomi, Demeyer, Sofie, Mentens, Nicole, Gielen, Olga, Provost, Sarah, Cools, Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Fondazione Ferrata Storti 2022
Materias:
Article - Acute Lymphoblastic Leukemia
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9521226/
https://www.ncbi.nlm.nih.gov/pubmed/35354248
http://dx.doi.org/10.3324/haematol.2021.279718

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9521226/
https://www.ncbi.nlm.nih.gov/pubmed/35354248
http://dx.doi.org/10.3324/haematol.2021.279718

Ejemplares similares