PTEN/PI3K/Akt pathway alters sensitivity of T-cell acute lymphoblastic leukemia to l-asparaginase

Childhood T-cell acute lymphoblastic leukemia (T-ALL) still remains a therapeutic challenge due to relapses which are resistant to further treatment. l-asparaginase (ASNase) is a key therapy component in pediatric T-ALL and lower sensitivity of leukemia cells to this drug negatively influences overa...

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Detalles Bibliográficos
Autores principales: Hlozkova, Katerina, Hermanova, Ivana, Safrhansova, Lucie, Alquezar-Artieda, Natividad, Kuzilkova, Daniela, Vavrova, Adela, Sperkova, Kristyna, Zaliova, Marketa, Stary, Jan, Trka, Jan, Starkova, Julia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8904819/
https://www.ncbi.nlm.nih.gov/pubmed/35260738
http://dx.doi.org/10.1038/s41598-022-08049-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8904819/
https://www.ncbi.nlm.nih.gov/pubmed/35260738
http://dx.doi.org/10.1038/s41598-022-08049-8

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