Molecular and Pharmacologic Properties of the Anticancer Quinolone Derivative Vosaroxin: A New Therapeutic Agent for Acute Myeloid Leukemia

Vosaroxin is a first-in-class anticancer quinolone derivative that targets topoisomerase II and induces site-selective double-strand breaks in DNA, leading to tumor cell apoptosis. Vosaroxin has chemical and pharmacologic characteristics distinct from other topoisomerase II inhibitors due to its qui...

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Detalles Bibliográficos
Autores principales: Jamieson, Gene C., Fox, Judith A., Poi, Ming, Strickland, Stephen A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2016
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4989016/
https://www.ncbi.nlm.nih.gov/pubmed/27484675
http://dx.doi.org/10.1007/s40265-016-0614-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4989016/
https://www.ncbi.nlm.nih.gov/pubmed/27484675
http://dx.doi.org/10.1007/s40265-016-0614-z

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