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Molecular and Pharmacologic Properties of the Anticancer Quinolone Derivative Vosaroxin: A New Therapeutic Agent for Acute Myeloid Leukemia

Vosaroxin is a first-in-class anticancer quinolone derivative that targets topoisomerase II and induces site-selective double-strand breaks in DNA, leading to tumor cell apoptosis. Vosaroxin has chemical and pharmacologic characteristics distinct from other topoisomerase II inhibitors due to its qui...

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Detalles Bibliográficos
Autores principales:	Jamieson, Gene C., Fox, Judith A., Poi, Ming, Strickland, Stephen A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer International Publishing 2016
Materias:	Review Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4989016/ https://www.ncbi.nlm.nih.gov/pubmed/27484675 http://dx.doi.org/10.1007/s40265-016-0614-z

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