Gene expression changes in damaged osteoarthritic cartilage identify a signature of non-chondrogenic and mechanical responses

OBJECTIVES: Joint degeneration in osteoarthritis (OA) is characterised by damage and loss of articular cartilage. The pattern of loss is consistent with damage occurring only where the mechanical loading is high. We have investigated using RNA-sequencing (RNA-seq) and systems analyses the changes th...

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Detalles Bibliográficos
Autores principales: Dunn, S.L., Soul, J., Anand, S., Schwartz, J.-M., Boot-Handford, R.P., Hardingham, T.E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: W.B. Saunders For The Osteoarthritis Research Society 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4989048/
https://www.ncbi.nlm.nih.gov/pubmed/26973327
http://dx.doi.org/10.1016/j.joca.2016.03.007

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4989048/
https://www.ncbi.nlm.nih.gov/pubmed/26973327
http://dx.doi.org/10.1016/j.joca.2016.03.007

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