Spatial Colocalization of Human Ohnolog Pairs Acts to Maintain Dosage-Balance

Ohnologs –paralogous gene pairs generated by whole genome duplication– are enriched for dosage sensitive genes, that is, genes that have a phenotype due to copy number changes. Dosage sensitive genes frequently occur in the same metabolic pathway and in physically interacting proteins. Accumulating...

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Detalles Bibliográficos
Autores principales: Xie, Ting, Yang, Qing-Yong, Wang, Xiao-Tao, McLysaght, Aoife, Zhang, Hong-Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Discoveries
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4989111/
https://www.ncbi.nlm.nih.gov/pubmed/27297469
http://dx.doi.org/10.1093/molbev/msw108

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4989111/
https://www.ncbi.nlm.nih.gov/pubmed/27297469
http://dx.doi.org/10.1093/molbev/msw108

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