Improved variants of SrtA for site-specific conjugation on antibodies and proteins with high efficiency

Sortase mediated ligation is a highly specific platform for conjugation that relies on the specificity of the transpeptidase Sortase A (SrtA) for short peptide sequences (LPXTG and GGG). SrtA retains its specificity while accepting a wide range of potential substrates, but its broad use is limited b...

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Detalles Bibliográficos
Autores principales: Chen, Long, Cohen, Justin, Song, Xiaoda, Zhao, Aishan, Ye, Zi, Feulner, Christine J., Doonan, Patrick, Somers, Will, Lin, Laura, Chen, Peng R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4989145/
https://www.ncbi.nlm.nih.gov/pubmed/27534437
http://dx.doi.org/10.1038/srep31899

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4989145/
https://www.ncbi.nlm.nih.gov/pubmed/27534437
http://dx.doi.org/10.1038/srep31899

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