Interleukin-21 signaling in B cells, but not in T cells, is indispensable for the development of collagen-induced arthritis in mice

BACKGROUND: Interleukin-21 (IL-21) is a T-cell-derived cytokine whose receptor is expressed on a variety of cells and therefore might have pleiotropic roles in the pathogenesis of rheumatoid arthritis (RA). In this study, we investigated the involvement of IL-21 signaling in the development of colla...

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Detalles Bibliográficos
Autores principales: Sakuraba, Koji, Oyamada, Akiko, Fujimura, Kenjiro, Spolski, Rosanne, Iwamoto, Yukihide, Leonard, Warren J., Yoshikai, Yasunobu, Yamada, Hisakata
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4989522/
https://www.ncbi.nlm.nih.gov/pubmed/27535236
http://dx.doi.org/10.1186/s13075-016-1086-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4989522/
https://www.ncbi.nlm.nih.gov/pubmed/27535236
http://dx.doi.org/10.1186/s13075-016-1086-y

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