EWS Knockdown and Taxifolin Treatment Induced Differentiation and Removed DNA Methylation from p53 Promoter to Promote Expression of Puma and Noxa for Apoptosis in Ewing’s Sarcoma

Ewing’s sarcoma is a pediatric tumor that mainly occurs in soft tissues and bones. Malignant characteristics of Ewing’s sarcoma are correlated with expression of EWS oncogene. We achieved knockdown of EWS expression using a plasmid vector encoding EWS short hairpin RNA (shRNA) to increase anti-tumor...

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Detalles Bibliográficos
Autores principales: Hossain, Mohammad Motarab, Ray, Swapan Kumar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4989871/
https://www.ncbi.nlm.nih.gov/pubmed/27547487
http://dx.doi.org/10.4236/jct.2014.512114

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4989871/
https://www.ncbi.nlm.nih.gov/pubmed/27547487
http://dx.doi.org/10.4236/jct.2014.512114

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