Frequent hypermethylation of orphan CpG islands with enhancer activity in cancer

BACKGROUND: CpG islands (CGIs) are interspersed DNA sequences that have unusually high CpG ratios and GC contents. CGIs are typically located in the promoter of protein-coding genes. They normally lack DNA methylation but become hypermethylated and induce repression of associated genes in cancer. Ho...

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Detalles Bibliográficos
Autores principales: Bae, Min Gyun, Kim, Jeong Yeon, Choi, Jung Kyoon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4989897/
https://www.ncbi.nlm.nih.gov/pubmed/27534853
http://dx.doi.org/10.1186/s12920-016-0198-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4989897/
https://www.ncbi.nlm.nih.gov/pubmed/27534853
http://dx.doi.org/10.1186/s12920-016-0198-1

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