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Frequent hypermethylation of orphan CpG islands with enhancer activity in cancer
BACKGROUND: CpG islands (CGIs) are interspersed DNA sequences that have unusually high CpG ratios and GC contents. CGIs are typically located in the promoter of protein-coding genes. They normally lack DNA methylation but become hypermethylated and induce repression of associated genes in cancer. Ho...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2016
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4989897/ https://www.ncbi.nlm.nih.gov/pubmed/27534853 http://dx.doi.org/10.1186/s12920-016-0198-1 |