Opposing roles of RNF8/RNF168 and deubiquitinating enzymes in ubiquitination-dependent DNA double-strand break response signaling and DNA-repair pathway choice

The E3 ubiquitin ligases ring finger protein (RNF) 8 and RNF168 transduce the DNA double-strand break (DSB) response (DDR) signal by ubiquitinating DSB sites. The depletion of RNF8 or RNF168 suppresses the accumulation of DNA-repair regulating factors such as 53BP1 and RAP80 at DSB sites, suggesting...

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Detalles Bibliográficos
Autor principal: Nakada, Shinichiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Supplement – ICRR highlights
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4990112/
https://www.ncbi.nlm.nih.gov/pubmed/26983989
http://dx.doi.org/10.1093/jrr/rrw027

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4990112/
https://www.ncbi.nlm.nih.gov/pubmed/26983989
http://dx.doi.org/10.1093/jrr/rrw027

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