Yap reprograms glutamine metabolism to increase nucleotide biosynthesis and enable liver growth

The Hippo pathway is an important regulator of organ size and tumorigenesis. It is unclear, however, how Hippo signaling provides the cellular building blocks required for rapid growth. Here, we demonstrate that transgenic zebrafish expressing an activated form of the Hippo pathway effector Yap1 (al...

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Detalles Bibliográficos
Autores principales: Cox, Andrew G., Hwang, Katie L., Brown, Kristin K., Evason, Kimberley, Beltz, Sebastian, Tsomides, Allison, O'Connor, Keelin, Galli, Giorgio G., Yimlamai, Dean, Chhangawala, Sagar, Yuan, Min, Lien, Evan C., Wucherpfennig, Julia, Nissim, Sahar, Minami, Akihiro, Cohen, David E., Camargo, Fernando D., Asara, John M., Houvras, Yariv, Stainier, Didier Y.R., Goessling, Wolfram
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4990146/
https://www.ncbi.nlm.nih.gov/pubmed/27428308
http://dx.doi.org/10.1038/ncb3389

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4990146/
https://www.ncbi.nlm.nih.gov/pubmed/27428308
http://dx.doi.org/10.1038/ncb3389

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