Maternal Exposure of Rats to Isoflurane during Late Pregnancy Impairs Spatial Learning and Memory in the Offspring by Up-Regulating the Expression of Histone Deacetylase 2

Increasing evidence indicates that most general anesthetics can harm developing neurons and induce cognitive dysfunction in a dose- and time-dependent manner. Histone deacetylase 2 (HDAC2) has been implicated in synaptic plasticity and learning and memory. Our previous results showed that maternal e...

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Detalles Bibliográficos
Autores principales: Luo, Foquan, Hu, Yan, Zhao, Weilu, Zuo, Zhiyi, Yu, Qi, Liu, Zhiyi, Lin, Jiamei, Feng, Yunlin, Li, Binda, Wu, Liuqin, Xu, Lin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4990207/
https://www.ncbi.nlm.nih.gov/pubmed/27536989
http://dx.doi.org/10.1371/journal.pone.0160826

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4990207/
https://www.ncbi.nlm.nih.gov/pubmed/27536989
http://dx.doi.org/10.1371/journal.pone.0160826

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