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Maternal Exposure of Rats to Isoflurane during Late Pregnancy Impairs Spatial Learning and Memory in the Offspring by Up-Regulating the Expression of Histone Deacetylase 2
Increasing evidence indicates that most general anesthetics can harm developing neurons and induce cognitive dysfunction in a dose- and time-dependent manner. Histone deacetylase 2 (HDAC2) has been implicated in synaptic plasticity and learning and memory. Our previous results showed that maternal e...
Autores principales: | Luo, Foquan, Hu, Yan, Zhao, Weilu, Zuo, Zhiyi, Yu, Qi, Liu, Zhiyi, Lin, Jiamei, Feng, Yunlin, Li, Binda, Wu, Liuqin, Xu, Lin |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4990207/ https://www.ncbi.nlm.nih.gov/pubmed/27536989 http://dx.doi.org/10.1371/journal.pone.0160826 |
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