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Histone deacetylase 6 structure and molecular basis of catalysis and inhibition
Histone deacetylase 6 (HDAC6) is a critical target for drug design due to its role in oncogenic transformation and cancer metastasis, and is unique among all histone deacetylases in that it contains tandem catalytic domains designated CD1 and CD2. We now report the crystal structures of CD2 from Hom...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4990478/ https://www.ncbi.nlm.nih.gov/pubmed/27454933 http://dx.doi.org/10.1038/nchembio.2134 |