Structural analysis of Notch-regulating Rumi reveals basis for pathogenic mutations

Rumi O-glucosylates the EGF repeats of a growing list of proteins essential in metazoan development including Notch. Rumi is essential for Notch signaling, and Rumi dysregulation is linked to several human diseases. Despite Rumi’s critical roles, it is unknown how Rumi glucosylates a serine of many...

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Detalles Bibliográficos
Autores principales: Yu, Hongjun, Takeuchi, Hideyuki, Takeuchi, Megumi, Liu, Qun, Kantharia, Joshua, Haltiwanger, Robert S., Li, Huilin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4990500/
https://www.ncbi.nlm.nih.gov/pubmed/27428513
http://dx.doi.org/10.1038/nchembio.2135

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4990500/
https://www.ncbi.nlm.nih.gov/pubmed/27428513
http://dx.doi.org/10.1038/nchembio.2135

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