Human TRAV1-2-negative MR1-restricted T cells detect S. pyogenes and alternatives to MAIT riboflavin-based antigens

Mucosal-associated invariant T (MAIT) cells are thought to detect microbial antigens presented by the HLA-Ib molecule MR1 through the exclusive use of a TRAV1-2-containing TCRα. Here we use MR1 tetramer staining and ex vivo analysis with mycobacteria-infected MR1-deficient cells to demonstrate the p...

Descripción completa

Detalles Bibliográficos
Autores principales: Meermeier, Erin W., Laugel, Bruno F., Sewell, Andrew K., Corbett, Alexandra J., Rossjohn, Jamie, McCluskey, James, Harriff, Melanie J., Franks, Tamera, Gold, Marielle C., Lewinsohn, David M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4990709/
https://www.ncbi.nlm.nih.gov/pubmed/27527800
http://dx.doi.org/10.1038/ncomms12506

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4990709/
https://www.ncbi.nlm.nih.gov/pubmed/27527800
http://dx.doi.org/10.1038/ncomms12506

Ejemplares similares