Function of high-mobility group A proteins in the DNA damage signaling for the induction of apoptosis

O(6)-Methylguanine produced in DNA can pair with thymine during DNA replication, thus leading to a G-to-A transition mutation. To prevent such outcomes, cells harboring O(6)-methylguanine-containing mispair undergo apoptosis that requires the function of mismatch repair (MMR) protein complex. To ide...

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Detalles Bibliográficos
Autores principales: Fujikane, Ryosuke, Komori, Kayoko, Sekiguchi, Mutsuo, Hidaka, Masumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4990841/
https://www.ncbi.nlm.nih.gov/pubmed/27538817
http://dx.doi.org/10.1038/srep31714

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4990841/
https://www.ncbi.nlm.nih.gov/pubmed/27538817
http://dx.doi.org/10.1038/srep31714

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