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Function of high-mobility group A proteins in the DNA damage signaling for the induction of apoptosis
O(6)-Methylguanine produced in DNA can pair with thymine during DNA replication, thus leading to a G-to-A transition mutation. To prevent such outcomes, cells harboring O(6)-methylguanine-containing mispair undergo apoptosis that requires the function of mismatch repair (MMR) protein complex. To ide...
Autores principales: | Fujikane, Ryosuke, Komori, Kayoko, Sekiguchi, Mutsuo, Hidaka, Masumi |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4990841/ https://www.ncbi.nlm.nih.gov/pubmed/27538817 http://dx.doi.org/10.1038/srep31714 |
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