Microbial Cryptotopes are Prominent Targets of B-cell Immunity

B-cell recognition of microbial antigens may be limited by masking of epitopes within three-dimensional structures (cryptotopes). Here we report that unmasking of cryptotopes by unfolding whole cytomegalovirus (CMV) antigen preparations with the chaotropic reagent Urea and probing with immune sera f...

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Detalles Bibliográficos
Autores principales: Rieder, Franz J. J., Biebl, Julia, Kastner, Marie-Theres, Schneider, Martina, Jungbauer, Christof, Redlberger-Fritz, Monika, Britt, William J., Kundi, Michael, Steininger, Christoph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4990913/
https://www.ncbi.nlm.nih.gov/pubmed/27539094
http://dx.doi.org/10.1038/srep31657

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4990913/
https://www.ncbi.nlm.nih.gov/pubmed/27539094
http://dx.doi.org/10.1038/srep31657

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