Parkinson disease-linked GBA mutation effects reversed by molecular chaperones in human cell and fly models

GBA gene mutations are the greatest cause of Parkinson disease (PD). GBA encodes the lysosomal enzyme glucocerebrosidase (GCase) but the mechanisms by which loss of GCase contributes to PD remain unclear. Inhibition of autophagy and the generation of endoplasmic reticulum (ER) stress are both implic...

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Detalles Bibliográficos
Autores principales: Sanchez-Martinez, Alvaro, Beavan, Michelle, Gegg, Matthew E., Chau, Kai-Yin, Whitworth, Alexander J., Schapira, Anthony H. V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4990939/
https://www.ncbi.nlm.nih.gov/pubmed/27539639
http://dx.doi.org/10.1038/srep31380

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4990939/
https://www.ncbi.nlm.nih.gov/pubmed/27539639
http://dx.doi.org/10.1038/srep31380

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