Cargando…

Investigating the Molecular Basis of PPCD3: Characterization of ZEB1 Regulation of COL4A3 Expression

PURPOSE: To investigate the role of the zinc finger e-box binding homeobox 1 (ZEB1) transcription factor in posterior polymorphous corneal dystrophy 3 by demonstrating its ability to regulate type IV collagen gene transcription via binding to putative E2 box motifs. METHODS: Putative E2 box motifs w...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chung, Duk-Won D., Frausto, Ricardo F., Chiu, Stephan, Lin, Benjamin R., Aldave, Anthony J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Association for Research in Vision and Ophthalmology 2016
Materias:	Cornea
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4991021/ https://www.ncbi.nlm.nih.gov/pubmed/27537263 http://dx.doi.org/10.1167/iovs.16-19533

Ejemplares similares

Elucidating the molecular basis of PPCD: Effects of decreased ZEB1 expression on corneal endothelial cell function
por: Zakharevich, Marina, et al.
Publicado: (2017)

Transcriptomic Profiling of Posterior Polymorphous Corneal Dystrophy
por: Chung, Doug D., et al.
Publicado: (2017)

Energy Shortage in Human and Mouse Models of SLC4A11-Associated Corneal Endothelial Dystrophies
por: Zhang, Wenlin, et al.
Publicado: (2020)

ZEB1 Mediates Fibrosis in Corneal Endothelial Mesenchymal Transition Through SP1 and SP3
por: Lee, JeongGoo, et al.
Publicado: (2020)

COL8A2 Regulates the Fate of Corneal Endothelial Cells
por: Hwang, Jin Sun, et al.
Publicado: (2020)

Retinal pathology in the PPCD1 mouse
por: Shen, Anna L., et al.
Publicado: (2017)

Efficacy of hyaluronic acid 0.3%, cyanocobalamin, electrolytes, and P-Plus in menopause patients with moderate dry eye disease
por: De-Hita-Cantalejo, Concepción, et al.
Publicado: (2021)

METTL3 Attenuates Inflammation in Fusarium solani–Induced Keratitis via the PI3K/AKT Signaling Pathway
por: Huang, Liwei, et al.
Publicado: (2022)

ω-3 Tear Film Lipids Correlate With Clinical Measures of Dry Eye
por: Walter, Scott D., et al.
Publicado: (2016)

IGFBP-3 Mediates Metabolic Homeostasis During Hyperosmolar Stress in the Corneal Epithelium
por: Bogdan, Evan D., et al.
Publicado: (2021)

PPCD: Privacy-preserving clinical decision with cloud support
por: Ma, Hui, et al.
Publicado: (2019)

Characterization of the Limbal Epithelial Stem Cell Niche
por: Moreno, Isabel Y., et al.
Publicado: (2023)

Keratan Sulfate Phenotype in the β-1,3-N-Acetylglucosaminyltransferase-7–Null Mouse Cornea
por: Littlechild, Stacy L., et al.
Publicado: (2018)

Colocalization of Galectin-3 With CD147 Is Associated With Increased Gelatinolytic Activity in Ulcerating Human Corneas
por: Cruzat, Andrea, et al.
Publicado: (2018)

Indoleamine 2,3-Dioxygenase Regulates Macrophage Recruitment, Polarization and Phagocytosis in Aspergillus Fumigatus Keratitis
por: Jiang, Nan, et al.
Publicado: (2020)

The Structural Role of Elastic Fibers in the Cornea Investigated Using a Mouse Model for Marfan Syndrome
por: White, Tomas L., et al.
Publicado: (2017)

Galectin-3 Inhibition by a Small-Molecule Inhibitor Reduces Both Pathological Corneal Neovascularization and Fibrosis
por: Chen*, Wei-Sheng, et al.
Publicado: (2017)

PDGFRα Is a Key Regulator of T1 and T3's Differential Effect on SMA Expression in Human Corneal Fibroblasts
por: Sriram, Sriniwas, et al.
Publicado: (2017)

Inhibition of miR-665-3p Enhances Autophagy and Alleviates Inflammation in Fusarium solani-Induced Keratitis
por: Guo, Qunqin, et al.
Publicado: (2021)

An Investigation of the Effects of Riboflavin Concentration on the Efficacy of Corneal Cross-Linking Using an Enzymatic Resistance Model in Porcine Corneas
por: O'Brart, Naomi A. L., et al.
Publicado: (2019)

Isolation and Characterization of Human Conjunctival Mesenchymal Stromal Cells and Their Extracellular Vesicles
por: García-Posadas, Laura, et al.
Publicado: (2023)

The NLRP3 Activation in Infiltrating Macrophages Contributes to Corneal Fibrosis by Inducing TGF-β1 Expression in the Corneal Epithelium
por: Xu, Jing, et al.
Publicado: (2022)

Quasi-Static Optical Coherence Elastography to Characterize Human Corneal Biomechanical Properties
por: Kling, Sabine, et al.
Publicado: (2020)

Labial Mucosa Stem Cells: Isolation, Characterization, and Their Potential for Corneal Epithelial Reconstruction
por: Zhurenkov, Kirill E., et al.
Publicado: (2022)

Molecular and Phenotypic Characterization of Ocular Methicillin-Resistant Staphylococcus epidermidis Isolates in Taiwan
por: Chang, Yin-Hsi, et al.
Publicado: (2023)

MiR-223-3p Regulates Autophagy and Inflammation by Targeting ATG16L1 in Fusarium solani–Induced Keratitis
por: Tang, Hanfeng, et al.
Publicado: (2022)

HC-HA/PTX3 Purified From Human Amniotic Membrane Reverts Human Corneal Fibroblasts and Myofibroblasts to Keratocytes by Activating BMP Signaling
por: Zhu, Ying-Ting, et al.
Publicado: (2020)

Administration of Menadione, Vitamin K3, Ameliorates Off-Target Effects on Corneal Epithelial Wound Healing Due to Receptor Tyrosine Kinase Inhibition
por: Rush, Jamie S., et al.
Publicado: (2016)

Individualized Characterization of the Distribution of Collagen Fibril Dispersion Using Optical Aberrations of the Cornea for Biomechanical Models
por: Xu, Mengchen, et al.
Publicado: (2020)

Diabetic Neuropathy Is Characterized by Progressive Corneal Nerve Fiber Loss in the Central and Inferior Whorl Regions
por: Ferdousi, Maryam, et al.
Publicado: (2020)

Morphological characterization and clinical effects of stromal alterations after intracorneal ring segment implantation in keratoconus
por: Hamon, Loïc, et al.
Publicado: (2022)

UV-A Irradiation Activates Nrf2-Regulated Antioxidant Defense and Induces p53/Caspase3-Dependent Apoptosis in Corneal Endothelial Cells
por: Liu, Cailing, et al.
Publicado: (2016)

Screening and Characterization of Drugs That Protect Corneal Endothelial Cells Against Unfolded Protein Response and Oxidative Stress
por: Kim, Eun Chul, et al.
Publicado: (2017)

Inhibition of the m6A Methyltransferase METTL3 Attenuates the Inflammatory Response in Fusarium solani-Induced Keratitis via the NF-κB Signaling Pathway
por: Tang, Hanfeng, et al.
Publicado: (2022)

Celastrol Alleviates Corneal Stromal Fibrosis by Inhibiting TGF-β1/Smad2/3-YAP/TAZ Signaling After Descemet Stripping Endothelial Keratoplasty
por: Liu, Ruixing, et al.
Publicado: (2023)

Surface epithelialization of the type I Boston keratoprosthesis front plate: immunohistochemical and high-definition optical coherence tomography characterization
por: Kiang, Lee, et al.
Publicado: (2012)

Generation and Characterization of a Novel Mouse Line, Keratocan-rtTA (Kera(RT)), for Corneal Stroma and Tendon Research
por: Zhang, Yujin, et al.
Publicado: (2017)

S100A4 Silencing Facilitates Corneal Wound Healing After Alkali Burns by Promoting Autophagy via Blocking the PI3K/Akt/mTOR Signaling Pathway
por: Wang, Yulin, et al.
Publicado: (2020)

Topographic, tomographic, and corneal wavefront asymmetry in keratoconus: towards an eye asymmetry index EASIX
por: Mehlan, Juliane, et al.
Publicado: (2022)

Correlation between central stromal demarcation line depth and changes in K values after corneal cross-linking (CXL)
por: Pircher, Niklas, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_ktjpavbjog9kaghj5e6i0ovsvl