FR-900098, an antimalarial development candidate that inhibits the non-mevalonate isoprenoid biosynthesis pathway, shows no evidence of acute toxicity and genotoxicity

FR-900098 is an inhibitor of 1-deoxy-d-xylulose-5-phosphate (DXP) reductoisomerase, the second enzyme in the non-mevalonate isoprenoid biosynthesis pathway. In previous studies, FR-900098 was shown to possess potent antimalarial activity in vitro and in a murine malaria model. In order to provide a...

Descripción completa

Detalles Bibliográficos
Autores principales: Wiesner, Jochen, Ziemann, Christina, Hintz, Martin, Reichenberg, Armin, Ortmann, Regina, Schlitzer, Martin, Fuhst, Rainer, Timmesfeld, Nina, Vilcinskas, Andreas, Jomaa, Hassan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4991342/
https://www.ncbi.nlm.nih.gov/pubmed/27260413
http://dx.doi.org/10.1080/21505594.2016.1195537

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4991342/
https://www.ncbi.nlm.nih.gov/pubmed/27260413
http://dx.doi.org/10.1080/21505594.2016.1195537

Ejemplares similares