Methylomic predictors demonstrate the role of NF-κB in old-age mortality and are unrelated to the aging-associated epigenetic drift

Changes in the DNA methylation (DNAm) landscape have been implicated in aging and cellular senescence. To unravel the role of specific DNAm patterns in late-life survival, we performed genome-wide methylation profiling in nonagenarians (n=111) and determined the performance of the methylomic predict...

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Detalles Bibliográficos
Autores principales: Jylhävä, Juulia, Kananen, Laura, Raitanen, Jani, Marttila, Saara, Nevalainen, Tapio, Hervonen, Antti, Jylhä, Marja, Hurme, Mikko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper: Gerotarget (Focus on Aging)
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4991378/
https://www.ncbi.nlm.nih.gov/pubmed/27015559
http://dx.doi.org/10.18632/oncotarget.8278

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4991378/
https://www.ncbi.nlm.nih.gov/pubmed/27015559
http://dx.doi.org/10.18632/oncotarget.8278

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