ZSTK474, a specific class I phosphatidylinositol 3-kinase inhibitor, induces G1 arrest and autophagy in human breast cancer MCF-7 cells

Multifaceted activities of class I phosphatidylinositol 3-kinase (PI3K) inhibitor ZSTK474 were investigated on human breast cancer cell MCF-7. ZSTK474 inhibited proliferation of MCF-7 cells potently. Flow cytometric analysis indicated that ZSTK474 induced cell cycle arrest at G1 phase, but no obviou...

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Detalles Bibliográficos
Autores principales: Wang, Yaochen, Liu, Jing, Qiu, Yuling, Jin, Meihua, Chen, Xi, Fan, Guanwei, Wang, Ran, Kong, Dexin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4991426/
https://www.ncbi.nlm.nih.gov/pubmed/26918351
http://dx.doi.org/10.18632/oncotarget.7658

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4991426/
https://www.ncbi.nlm.nih.gov/pubmed/26918351
http://dx.doi.org/10.18632/oncotarget.7658

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