Fibroblast-induced switching to the mesenchymal-like phenotype and PI3K/mTOR signaling protects melanoma cells from BRAF inhibitors

The knowledge on how tumor-associated stroma influences efficacy of anti-cancer therapy just started to emerge. Here we show that lung fibroblasts reduce melanoma sensitivity to the BRAF inhibitor (BRAFi) vemurafenib only if the two cell types are in close proximity. In the presence of fibroblasts,...

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Detalles Bibliográficos
Autores principales: Seip, Kotryna, Fleten, Karianne G., Barkovskaya, Anna, Nygaard, Vigdis, Haugen, Mads H., Engesæter, Birgit Ø., Mælandsmo, Gunhild M., Prasmickaite, Lina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4991434/
https://www.ncbi.nlm.nih.gov/pubmed/26918352
http://dx.doi.org/10.18632/oncotarget.7671

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4991434/
https://www.ncbi.nlm.nih.gov/pubmed/26918352
http://dx.doi.org/10.18632/oncotarget.7671

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