Signal transducer and activator of transcription 3 (STAT3) inhibitor, S3I-201, acts as a potent and non-selective alkylating agent

The Signal Transducer and Activator of Transcription 3 (STAT3) oncogene is a master regulator of many human cancers, and a well-recognized target for therapeutic intervention. A well known STAT3 inhibitor, S3I-201 (NSC 74859), is hypothesized to block STAT3 function in cancer cells by binding the ST...

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Detalles Bibliográficos
Autores principales: Ball, Daniel P., Lewis, Andrew M., Williams, Declan, Resetca, Diana, Wilson, Derek J., Gunning, Patrick T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4991483/
https://www.ncbi.nlm.nih.gov/pubmed/26942696
http://dx.doi.org/10.18632/oncotarget.7838

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4991483/
https://www.ncbi.nlm.nih.gov/pubmed/26942696
http://dx.doi.org/10.18632/oncotarget.7838

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