Palladium-Catalyzed Modular Synthesis of Substituted Piperazines and Related Nitrogen Heterocycles

[Image: see text] We report here a novel method for the modular synthesis of highly substituted piperazines and related bis-nitrogen heterocycles via a palladium-catalyzed cyclization reaction. The process couples two of the carbons of a propargyl unit with various diamine components to provide nitr...

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Autores principales: Montgomery, Thomas D., Rawal, Viresh H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2016
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4991562/
https://www.ncbi.nlm.nih.gov/pubmed/26824482
http://dx.doi.org/10.1021/acs.orglett.5b03708
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author Montgomery, Thomas D.
Rawal, Viresh H.
author_facet Montgomery, Thomas D.
Rawal, Viresh H.
author_sort Montgomery, Thomas D.
collection PubMed
description [Image: see text] We report here a novel method for the modular synthesis of highly substituted piperazines and related bis-nitrogen heterocycles via a palladium-catalyzed cyclization reaction. The process couples two of the carbons of a propargyl unit with various diamine components to provide nitrogen heterocycles in generally good to excellent yields and high regio- and stereochemical control.
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spelling pubmed-49915622017-01-29 Palladium-Catalyzed Modular Synthesis of Substituted Piperazines and Related Nitrogen Heterocycles Montgomery, Thomas D. Rawal, Viresh H. Org Lett [Image: see text] We report here a novel method for the modular synthesis of highly substituted piperazines and related bis-nitrogen heterocycles via a palladium-catalyzed cyclization reaction. The process couples two of the carbons of a propargyl unit with various diamine components to provide nitrogen heterocycles in generally good to excellent yields and high regio- and stereochemical control. American Chemical Society 2016-01-29 2016-02-19 /pmc/articles/PMC4991562/ /pubmed/26824482 http://dx.doi.org/10.1021/acs.orglett.5b03708 Text en Copyright © 2016 American Chemical Society This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
spellingShingle Montgomery, Thomas D.
Rawal, Viresh H.
Palladium-Catalyzed Modular Synthesis of Substituted Piperazines and Related Nitrogen Heterocycles
title Palladium-Catalyzed Modular Synthesis of Substituted Piperazines and Related Nitrogen Heterocycles
title_full Palladium-Catalyzed Modular Synthesis of Substituted Piperazines and Related Nitrogen Heterocycles
title_fullStr Palladium-Catalyzed Modular Synthesis of Substituted Piperazines and Related Nitrogen Heterocycles
title_full_unstemmed Palladium-Catalyzed Modular Synthesis of Substituted Piperazines and Related Nitrogen Heterocycles
title_short Palladium-Catalyzed Modular Synthesis of Substituted Piperazines and Related Nitrogen Heterocycles
title_sort palladium-catalyzed modular synthesis of substituted piperazines and related nitrogen heterocycles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4991562/
https://www.ncbi.nlm.nih.gov/pubmed/26824482
http://dx.doi.org/10.1021/acs.orglett.5b03708
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