Cargando…

Trichostatin A increases the TIMP-1/MMP ratio to protect against osteoarthritis in an animal model of the disease

The histone deacetylase inhibitor trichostatin A (TSA) has been demonstrated to alleviate certain symptoms associated with osteoarthritis (OA). However, the exact mechanisms underlying this protective effect remain to be elucidated. The present study therefore examined the effects of TSA on the expr...

Descripción completa

Detalles Bibliográficos
Autores principales:	Qu, Hao, Li, Jin, Wu, Li-Dong, Chen, Wei-Ping
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	D.A. Spandidos 2016
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4991690/ https://www.ncbi.nlm.nih.gov/pubmed/27431944 http://dx.doi.org/10.3892/mmr.2016.5523

Ejemplares similares

The usefulness of MMP-9, TIMP-1 and MMP-9/TIMP-1 ratio for diagnosis and assessment of COPD severity
por: Dimic-Janjic, Sanja, et al.
Publicado: (2023)

Association between MMP3 and TIMP3 polymorphisms and risk of osteoarthritis
por: Tong, Zhichao, et al.
Publicado: (2017)

Association of Sepsis-Related Mortality with Early Increase of TIMP-1/MMP-9 Ratio
por: Lorente, Leonardo, et al.
Publicado: (2014)

Matrix metalloproteinase MMP-8, TIMP-1 and MMP-8/TIMP-1 ratio in plasma in methicillin-sensitive Staphylococcus aureus bacteremia
por: Forsblom, Erik, et al.
Publicado: (2021)

Influence of TIMP-1/MMP-9 ratio on the severity and mortality in sepsis
por: Lorente, L, et al.
Publicado: (2010)

Influence of TIMP-1/MMP-9 ratio on the severity and mortality in sepsis
por: Lorente, L, et al.
Publicado: (2011)

Expression and Roles of MMP-2, MMP-9, MMP-13, TIMP-1, and TIMP-2 in Allergic Nasal Mucosa
por: Mori, Sachiko, et al.
Publicado: (2012)

Expression of the metalloproteases MMP-1, MMP-2, MMP-3, MMP-9, MMP-11, TIMP-1 and TIMP-2 in angiocentric midfacial lymphomas
por: Meneses-García, Abelardo, et al.
Publicado: (2008)

Diagnostic values of MMP-7, MMP-9, MMP-11, TIMP-1, TIMP-2, CEA, and CA19-9 in patients with colorectal cancer
por: Huang, Xiwen, et al.
Publicado: (2021)

Evaluation of MMP-9 and MMP-2 and their suppressor TIMP-1 and TIMP-2 in adenocarcinoma of esophagogastric junction
por: Lu, Xiaofei, et al.
Publicado: (2016)

TIMP1 and MMP9 are predictors of mortality in septic patients in the emergency department and intensive care unit unlike MMP9/TIMP1 ratio: Multivariate model
por: Niño, Maria Eugenia, et al.
Publicado: (2017)

The increased of MMP-9 and MMP-2 with the decreased of TIMP-1 on the uterosacral ligament after childbirth
por: Rahajeng, Rahajeng
Publicado: (2018)

Expressions of Matrix Metalloproteinases (MMP-2, MMP-7, and MMP-9) and Their Inhibitors (TIMP-1, TIMP-2) in Inflammatory Bowel Diseases
por: Jakubowska, Katarzyna, et al.
Publicado: (2016)

MMP-2, MMP-9, TIMP-1, and TIMP-2 in the Peripheral Blood of Patients with Differentiated Thyroid Carcinoma
por: Zhang, Wen-jing, et al.
Publicado: (2019)

An evaluation of matrix metalloproteinase-9 (Mmp-9) and tissue inhibitor metalloproteinase-1 (Timp-1) Serum levels and the Mmp-9/Timp-1 Ratio in Covid-19 patients
por: Demir, Nazlim Aktug, et al.
Publicado: (2023)

The Imbalance of MMP-2/TIMP-2 and MMP-9/TIMP-1 Contributes to Collagen Deposition Disorder in Diabetic Non-Injured Skin
por: Zhou, Peng, et al.
Publicado: (2021)

MMP-9 and MMP-2 gelatinases and TIMP-1 and TIMP-2 inhibitors in breast cancer: correlations with prognostic factors
por: Jinga, D C, et al.
Publicado: (2006)

Plasma Glycosaminoglycan Profiles in Systemic Sclerosis: Associations with MMP-3, MMP-10, TIMP-1, TIMP-2, and TGF-Beta
por: Kuźnik-Trocha, Kornelia, et al.
Publicado: (2020)

TIMP-1, TIMP-2 and MMP-9 as prognostic markers for clinical outcome in sepsis
por: Hoffmann, U, et al.
Publicado: (2003)

Upregulation of matrix metalloproteinase 9 (MMP9)/tissue inhibitor of metalloproteinase 1 (TIMP1) and MMP2/TIMP2 ratios may be involved in lipopolysaccharide-induced acute lung injury
por: Chen, Guobing, et al.
Publicado: (2020)

Assessment of RANTES, MIP4A, MMP7, MMP9, MMP14, TIMP 1, TIMP 2 and TIMP 3 concentration in the follicular fluid of patients undergoing in vitro fertilization/embryo transfer procedure
por: Adamczak, Rafał, et al.
Publicado: (2023)

Upregulation and differential expression of matrilysin (MMP-7) and metalloelastase (MMP-12) and their inhibitors TIMP-1 and TIMP-3 in Barrett's oesophageal adenocarcinoma
por: Salmela, M T, et al.
Publicado: (2001)

MMP-2 and MMP-9 Activities and TIMP-1 and TIMP-2 Expression in the Prostatic Tissue of Two Ethanol-Preferring Rat Models
por: Fioruci-Fontanelli, Beatriz Aparecida, et al.
Publicado: (2015)

Blood flow interplays with elastin: collagen and MMP: TIMP ratios to maintain healthy vascular structure and function
por: Basu, Poulami, et al.
Publicado: (2010)

The Activity of Matrix Metalloproteinases (MMP-2, MMP-9) and Their Tissue Inhibitors (TIMP-1, TIMP-3) in the Cerebral Cortex and Hippocampus in Experimental Acanthamoebiasis
por: Łanocha-Arendarczyk, Natalia, et al.
Publicado: (2018)

Mechanisims of asthma and allergic disease – 1077. Differential expression and roles oF MMP-2, MMP-9, MMP-13, TIMP-1, and TIMP-2 in allergic rhinitis
por: Mori, Sachiko, et al.
Publicado: (2013)

hUMSCs Restore Uterine Function by Inhibiting Endometrial Fibrosis via Regulation of the MMP-9/TIMP-1 Ratio in CDDP-Induced Injury Rats
por: Tang, Yu, et al.
Publicado: (2023)

The influence of MMP-14, TIMP-2 and MMP-2 expression on breast cancer prognosis
por: Têtu, Bernard, et al.
Publicado: (2006)

Assessment of MMP-1, MMP-8 and TIMP-2 in experimental periodontitis treated with kaempferol
por: Balli, Umut, et al.
Publicado: (2016)

Regulation of MT1-MMP/MMP-2/TIMP-2 axis in human placenta
por: Vincent, Zoë L, et al.
Publicado: (2015)

Levels of Circulating TIMP-2 and MMP2-TIMP2 Complex Are Decreased in Squamous Cervical Carcinoma
por: Anne, Talvensaari-Mattila, et al.
Publicado: (2010)

Tumoral and stromal expression of MMP-2, MMP-9, MMP-14, TIMP-1, TIMP-2, and VEGF-A in cervical cancer patient survival: a competing risk analysis
por: Azevedo Martins, Jordana Maria, et al.
Publicado: (2020)

Trichostatin A Protects Liver against Septic Injury through Inhibiting Toll-Like Receptor Signaling
por: Kim, So-Jin, et al.
Publicado: (2016)

MMP-9 and TIMP-1 in placenta of hypertensive disorder complicating pregnancy
por: Zhang, Yuyi, et al.
Publicado: (2019)

Matrix metalloproteinases and diabetic foot ulcers: the ratio of MMP-1 to TIMP-1 is a predictor of wound healing
por: Muller, M, et al.
Publicado: (2008)

The evaluation of the MMP-2/TIMP-1 ratio in peptic ulcer and its association with refractory helicobacter pylori infection
por: Negaresh, Mohammad, et al.
Publicado: (2023)

Effect of osteopontin on TIMP-1 and TIMP-2 mRNA in chondrocytes of human knee osteoarthritis in vitro
por: ZHANG, FANG-JIE, et al.
Publicado: (2014)

Clinical impact of MMP and TIMP gene polymorphisms in gastric cancer
por: Kubben, F J G M, et al.
Publicado: (2006)

Total Flavonoids of Scutellaria barbata Inhibit Invasion of Hepatocarcinoma via MMP/TIMP in Vitro
por: Dai, Zhi-Jun, et al.
Publicado: (2013)

Dynamics of MMP-9, MMP-2 and TIMP-1 in a rat model of brain injury combined with traumatic heterotopic ossification
por: Shi, Wei-Zhe, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_5psd1eljeb1g9ntpgb0bl3ht6i