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Structural analysis of a signal peptide inside the ribosome tunnel by DNP MAS NMR

Proteins are synthesized in cells by ribosomes and, in parallel, prepared for folding or targeting. While ribosomal protein synthesis is progressing, the nascent chain exposes amino-terminal signal sequences or transmembrane domains that mediate interactions with specific interaction partners, such...

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Detalles Bibliográficos
Autores principales: Lange, Sascha, Franks, W. Trent, Rajagopalan, Nandhakishore, Döring, Kristina, Geiger, Michel A., Linden, Arne, van Rossum, Barth-Jan, Kramer, Günter, Bukau, Bernd, Oschkinat, Hartmut
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4991931/
https://www.ncbi.nlm.nih.gov/pubmed/27551685
http://dx.doi.org/10.1126/sciadv.1600379