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Orchestrated activation of mGluR5 and CB(1) promotes neuroprotection

The metabotropic glutamate receptor 5 (mGluR5) and the cannabinoid receptor 1 (CB(1)) exhibit a functional interaction, as CB(1) regulates pre-synaptic glutamate release and mGluR5 activation increases endocannabinoid synthesis at the post-synaptic site. Since both mGluR5 and CB(1) promote neuroprot...

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Detalles Bibliográficos
Autores principales: Batista, Edleusa M. L., Doria, Juliana G., Ferreira-Vieira, Talita H., Alves-Silva, Juliana, Ferguson, Stephen S. G., Moreira, Fabricio A., Ribeiro, Fabiola M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4992217/
https://www.ncbi.nlm.nih.gov/pubmed/27543109
http://dx.doi.org/10.1186/s13041-016-0259-6