Cargando…

Orchestrated activation of mGluR5 and CB(1) promotes neuroprotection

The metabotropic glutamate receptor 5 (mGluR5) and the cannabinoid receptor 1 (CB(1)) exhibit a functional interaction, as CB(1) regulates pre-synaptic glutamate release and mGluR5 activation increases endocannabinoid synthesis at the post-synaptic site. Since both mGluR5 and CB(1) promote neuroprot...

Descripción completa

Detalles Bibliográficos
Autores principales:	Batista, Edleusa M. L., Doria, Juliana G., Ferreira-Vieira, Talita H., Alves-Silva, Juliana, Ferguson, Stephen S. G., Moreira, Fabricio A., Ribeiro, Fabiola M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2016
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4992217/ https://www.ncbi.nlm.nih.gov/pubmed/27543109 http://dx.doi.org/10.1186/s13041-016-0259-6

Ejemplares similares

mGluR5, CB1 and neuroprotection
por: Carvalho, Toniana G., et al.
Publicado: (2016)

mGluR5 ablation leads to age-related synaptic plasticity impairments and does not improve Huntington’s disease phenotype
por: de Souza, Jessica M., et al.
Publicado: (2022)

mGluR5 regulates REST/NRSF signaling through N-cadherin/β-catenin complex in Huntington’s disease
por: de Souza, Jéssica M., et al.
Publicado: (2020)

Group I mGluRs in Therapy and Diagnosis of Parkinson’s Disease: Focus on mGluR5 Subtype
por: Azam, Shofiul, et al.
Publicado: (2022)

Metabotropic glutamate receptors (mGluRs) in epileptogenesis: an update on abnormal mGluRs signaling and its therapeutic implications
por: Huang, Leyi, et al.
Publicado: (2023)

Opposite Effects of mGluR1a and mGluR5 Activation on Nucleus Accumbens Medium Spiny Neuron Dendritic Spine Density
por: Gross, Kellie S., et al.
Publicado: (2016)

In Silico Analysis of the Association Relationship between Neuroprotection and Flavors of Traditional Chinese Medicine Based on the mGluRs
por: Zhang, Xu, et al.
Publicado: (2018)

Inhibition of Spontaneous Recovery of Fear by mGluR5 after Prolonged Extinction Training
por: Mao, Sheng-Chun, et al.
Publicado: (2013)

The orthosteric agonist 2-chloro-5-hydroxyphenylglycine activates mGluR5 and mGluR1 with similar efficacy and potency
por: Kammermeier, Paul J
Publicado: (2012)

The Changes in mGluR2 and mGluR7 Expression in Rat Medial Vestibular Nucleus and Flocculus Following Unilateral Labyrinthectomy
por: Zhou, Wen, et al.
Publicado: (2013)

Pretreatment with mGluR2 or mGluR3 Agonists Reduces Apoptosis Induced by Hypoxia-Ischemia in Neonatal Rat Brains
por: Bratek - Gerej, Ewelina, et al.
Publicado: (2021)

Investigating the role of mGluR2 versus mGluR3 in antipsychotic-like effects, sleep-wake architecture and network oscillatory activity using novel Han Wistar rats lacking mGluR2 expression
por: Wood, Christian M., et al.
Publicado: (2018)

Extinction-Dependent Alterations in Corticostriatal mGluR2/3 and mGluR7 Receptors following Chronic Methamphetamine Self-Administration in Rats
por: Schwendt, Marek, et al.
Publicado: (2012)

Correction: Inhibition of Spontaneous Recovery of Fear by mGluR5 after Prolonged Extinction Training
por: Mao, Sheng-Chun, et al.
Publicado: (2013)

Bioactive Benzofuran Derivatives from Cortex Mori Radicis, and Their Neuroprotective and Analgesic Activities Mediated by mGluR(1)
por: Wang, Ya-Nan, et al.
Publicado: (2017)

PET imaging of mGluR5 in Alzheimer’s disease
por: Mecca, Adam P., et al.
Publicado: (2020)

mGluR5 Is Substitutable for mGluR1 in Cerebellar Purkinje Cells for Motor Coordination, Developmental Synapse Elimination, and Motor Learning
por: Harbers, Maria, et al.
Publicado: (2022)

mGluR-dependent plasticity in rodent models of Alzheimer’s disease
por: Valdivia, Gonzalo, et al.
Publicado: (2023)

mGluR-Dependent Synaptic Plasticity in Drug-Seeking
por: Bellone, Camilla, et al.
Publicado: (2012)

Neurotoxic/Neuroprotective Effects of Clozapine and the Positive Allosteric Modulator of mGluR2 JNJ-46356479 in Human Neuroblastoma Cell Cultures
por: Gassó, Patricia, et al.
Publicado: (2023)

Disrupted mGluR5-Homer scaffolds mediate abnormal mGluR5 signaling, circuit function and behavior in a mouse model of Fragile X Syndrome
por: Ronesi, Jennifer A., et al.
Publicado: (2012)

Translational Concepts of mGluR5 in Synaptic Diseases of the Brain
por: Piers, Thomas M., et al.
Publicado: (2012)

Loss of retinoid X receptor gamma subunit impairs group 1 mGluR mediated electrophysiological responses and group 1 mGluR dependent behaviors
por: Upreti, Chirag, et al.
Publicado: (2021)

Selective Recruitment of Presynaptic and Postsynaptic Forms of mGluR-LTD
por: Sanderson, Thomas M., et al.
Publicado: (2022)

Transgenerational deep sequencing revealed hypermethylation of hippocampal mGluR1 gene with altered mRNA expression of mGluR5 and mGluR3 associated with behavioral changes in Sprague Dawley rats with history of prolonged febrile seizure
por: Alese, Oluwole Ojo, et al.
Publicado: (2019)

Intracellular mGluR5 plays a critical role in neuropathic pain
por: Vincent, Kathleen, et al.
Publicado: (2016)

Target validation: Weak selectivity of LY341495 for mGluR2 over mGluR4 makes glutamate a less selective agonist
por: McCullock, Tyler W., et al.
Publicado: (2019)

mGluR5 antagonism inhibits cocaine reinforcement and relapse by elevation of extracellular glutamate in the nucleus accumbens via a CB1 receptor mechanism
por: Li, Xia, et al.
Publicado: (2018)

Two routes to autism phenotypes via mGluR5
Publicado: (2012)

Therapeutic potential of mGluR5 targeting in Alzheimer's disease
por: Kumar, Anil, et al.
Publicado: (2015)

mGluR5 hypofunction is integral to glutamatergic dysregulation in schizophrenia
por: Wang, Hoau-Yan, et al.
Publicado: (2018)

Neuromodulation by mGluRs in Sound Localization Circuits in the Auditory Brainstem
por: Goel, Nupur, et al.
Publicado: (2020)

Reduced mGluR5 Activity Modulates Mitochondrial Function
por: Gonzalez-Lozano, Miguel A., et al.
Publicado: (2021)

Role for Astrocytes in mGluR-Dependent LTD in the Neocortex and Hippocampus
por: Lalo, Ulyana, et al.
Publicado: (2022)

mGluR5 in amygdala modulates fear memory generalization
por: Xuan, Shou-Min, et al.
Publicado: (2023)

Metabotropic glutamate receptor 5 (mGluR5) regulates bladder nociception
por: Crock, Lara W, et al.
Publicado: (2012)

Operant Sensation Seeking Requires Metabotropic Glutamate Receptor 5 (mGluR5)
por: Olsen, Christopher M., et al.
Publicado: (2010)

Novel mGluR- and CB1R-Independent Suppression of GABA Release Caused by a Contaminant of the Group I Metabotropic Glutamate Receptor Agonist, DHPG
por: Lafourcade, Carlos A., et al.
Publicado: (2009)

Autophagy is increased following either pharmacological or genetic silencing of mGluR5 signaling in Alzheimer’s disease mouse models
por: Abd-Elrahman, Khaled S., et al.
Publicado: (2018)

Metabotropic glutamate receptor 1 (mGluR1) and 5 (mGluR5) regulate late phases of LTP and LTD in the hippocampal CA1 region in vitro
por: Neyman, Sergey, et al.
Publicado: (2008)

Cannot write session to /tmp/vufind_sessions/sess_gk5fu92s2hp9tqhr2688ld462v