Dactolisib (NVP-BEZ235) toxicity in murine brain tumour models

BACKGROUND: Glioblastomas (GBMs) are highly malignant brain tumours with a poor prognosis, and current cytotoxic regimens provide only a limited survival benefit. The PI3K/Akt/mTOR pathway has been an attractive target for therapy due to its high activation in GBMs as well as other cancers. The dual...

Descripción completa

Detalles Bibliográficos
Autores principales: Netland, I. A., Førde, H. E., Sleire, L., Leiss, L., Rahman, M. A., Skeie, B. S., Gjerde, C. H., Enger, P. Ø., Goplen, D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4992256/
https://www.ncbi.nlm.nih.gov/pubmed/27542970
http://dx.doi.org/10.1186/s12885-016-2712-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4992256/
https://www.ncbi.nlm.nih.gov/pubmed/27542970
http://dx.doi.org/10.1186/s12885-016-2712-4

Ejemplares similares