A Novel T55A Variant of G(s) α Associated with Impaired cAMP Production, Bone Fragility, and Osteolysis

G-protein coupled receptors (GPCRs) mediate a wide spectrum of biological activities. The GNAS complex locus encodes the stimulatory alpha subunit of the guanine nucleotide binding protein (G(s)α) and regulates production of the second messenger cyclic AMP (cAMP). Loss-of-function GNAS mutations cla...

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Detalles Bibliográficos
Autores principales: Wentworth, Kelly, Hsing, Alyssa, Urrutia, Ashley, Zhu, Yan, Horvai, Andrew E., Bastepe, Murat, Hsiao, Edward C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4992514/
https://www.ncbi.nlm.nih.gov/pubmed/27579188
http://dx.doi.org/10.1155/2016/2691385

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4992514/
https://www.ncbi.nlm.nih.gov/pubmed/27579188
http://dx.doi.org/10.1155/2016/2691385

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